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Although pramlintide alone does not cause hypoglycemia, in combination with rapid acting meal time insulin the two drugs synergistically increase the risk of severe hypoglycemia (427)

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Furthermore, data suggests that the seizure risk is 10 times higher if you take between 450 mg to 600 mg per day

Another patient had to switch to an injection because the pill's dietary restrictions which involve taking it with a small amount of water and waiting 30 minutes before eating or drinking did not fit into their lifestyle, Hofflich said